Cao Bang Nickel-Copper Mine is located in Cao Bang Province, Vietnam, with open-pit mining, and a design capacity of 3000t/d. The ore body has a wide distribution range and low grade, which belongs to refractory copper-nickel sulfide ore rich in magnesium silicate minerals. By utilizing advanced mining software for multi-approach and multi-scenario technical analysis and comparison, a new efficient flotation process for copper-nickel sulfide ore was developed, striving to the fullest to maximize the project benefits.