This invention discloses a method for control of zinc sulfide concentrate particle size in the course of pressure leaching. The problem of conditioning tank plugging is solved by the control of operating condition in zinc sulfide concentrate pressure leaching process to ensure continuous and stable operation of the production system and improve the productivity of the system. In comparison with the single additive, the use of two leaching additives can greatly reduce the specific consumption of the additive. The addition of the effective additive can avoid the entrapped unreacted concentrate in the molten sulfur to ensure more complete reaction of the concentrate and improve the resource use ratio.